A confirmed acute case may not be reported as a probable chronic case (i.e. A confirmed acute case may be classified as a confirmed chronic case if a positive HCV viral detection test is reported one year or longer after acute case onset.
Jurisdictions tracking re-infection should also consider collecting data on prior treatment completion (when relevant and possible to document), treatment failure, change in reported genotype if that applies, and the known time frame for reinfection.įor probable chronic cases, the presence of a negative HCV viral detection test result, in the absence of criteria that would allow for confirmation, indicates that a case should not be classified as probable chronic and should not be reported to CDC.Ī new chronic case is a newly reported case that does not have evidence of being an acute case of HCV infection. Jurisdictions are encouraged to ensure that cases of HCV treatment failure are not classified as new cases of HCV infection to the extent that it can be determined. Other evidence of reinfection should be considered, including a report of a new genotype on a case that has previously cleared a different genotype. Under current treatment recommendations, those two negative tests should be at least three months apart, however, the timing may change as standard of care for HCV treatment evolves. However, negative HCV viral detection test results received on confirmed chronic cases, subsequent to an initial positive result, should be appended to case reports, as feasible, and considered for the purpose of data analysis by each jurisdiction.Įvidence for re-infection may include a case of confirmed chronic HCV infection that has at least two sequential negative HCV viral detection tests reported, indicative of treatment initiation and sustained virologic response, followed by a positive HCV viral detection test. If evidence indicating resolution of infection is received after a confirmed chronic case has been reported to CDC, the case report does not need to be modified as it was a confirmed case at the time of initial report. Cases that have evidence of having cleared the infection at time of initial report or are considered false positive should not be reported to CDC. Criteria to Distinguish a New Case from an Existing CaseĪll jurisdictions are encouraged to track negative HCV viral detection tests to document both spontaneous clearance of infection or sustained viral response to HCV treatment. No epidemiologic linkage is required for case classification. A positive test for antibodies to hepatitis C virus (anti-HCV).A positive test indicating presence of hepatitis C viral antigen(s) (HCV antigen).Positive hepatitis C virus detection test: Nucleic acid test (NAT) for HCV RNA positive (including qualitative, quantitative, or genotype testing), OR.The absence of a more likely diagnosis (which may include evidence of acute liver disease due to other causes or advanced liver disease due to pre-existing chronic Hepatitis C virus (HCV) infection or other causes, such as alcohol exposure, other viral hepatitis, hemochromatosis, etc.) Laboratory Criteria Peak elevated serum alanine aminotransferase (ALT) levels >200 IU/L,.Peak elevated total bilirubin levels ≥ 3.0 mg/dL, OR.CSTE Position Statement(s)Īll hepatitis C virus cases in each classification category should be > 36 months of age, unless known to have been exposed non-perinatally.
#TEXTUAL EVIDENCE DEFINITION HOW TO#
Surveillance case definitions are not intended to be used by healthcare providers for making a clinical diagnosis or determining how to meet an individual patient’s health needs. Surveillance case definitions enable public health officials to classify and count cases consistently across reporting jurisdictions.
#TEXTUAL EVIDENCE DEFINITION PLUS#
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